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Year Number of Results
2008 1
2009 1
2010 2
2011 5
2012 7
2013 1
2014 6
2015 7
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2017 9
2018 9
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2020 9
2021 10
2022 5
2023 7
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81 results

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Page 1
Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells.
Desideri E, Castelli S, Dorard C, Toifl S, Grazi GL, Ciriolo MR, Baccarini M. Desideri E, et al. Autophagy. 2023 Jan;19(1):152-162. doi: 10.1080/15548627.2022.2063004. Epub 2022 Apr 18. Autophagy. 2023. PMID: 35435804 Free PMC article.
Here, we demonstrate that YAP1 and IL6ST are novel substrates of chaperone-mediated autophagy (CMA) in human hepatocellular carcinoma (HCC) and hepatocyte cell lines. Knockdown of the lysosomal CMA receptor LAMP2A increases protein levels of YAP1 and IL6ST, without …
Here, we demonstrate that YAP1 and IL6ST are novel substrates of chaperone-mediated autophagy (CMA) in human hepatocellular carcin …
Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production.
Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T. Myojin Y, et al. Gastroenterology. 2021 Apr;160(5):1741-1754.e16. doi: 10.1053/j.gastro.2020.12.015. Epub 2020 Dec 17. Gastroenterology. 2021. PMID: 33346004 Free article.
BACKGROUND & AIMS: Although the tumor microenvironment plays an important role in tumor growth, it is not fully understood what role hepatic stellate cells (HSCs) play in the hepatocellular carcinoma (HCC) microenvironment. METHODS: A high-fat diet after strepto …
BACKGROUND & AIMS: Although the tumor microenvironment plays an important role in tumor growth, it is not fully understood what role hep …
Good or not good: Role of miR-18a in cancer biology.
Kolenda T, Guglas K, Kopczyńska M, Sobocińska J, Teresiak A, Bliźniak R, Lamperska K. Kolenda T, et al. Rep Pract Oncol Radiother. 2020 Sep-Oct;25(5):808-819. doi: 10.1016/j.rpor.2020.07.006. Epub 2020 Aug 12. Rep Pract Oncol Radiother. 2020. PMID: 32884453 Free PMC article. Review.
HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G(1)/S cycle.
Lei Y, Xu X, Liu H, Chen L, Zhou H, Jiang J, Yang Y, Wu B. Lei Y, et al. Autophagy. 2021 Dec;17(12):4423-4441. doi: 10.1080/15548627.2021.1917948. Epub 2021 Apr 27. Autophagy. 2021. PMID: 33866937 Free PMC article.
The hepatitis B virus X protein (HBx) is involved in the process of hepatocellular carcinoma via the activation of various oncogenes. Our previous study indicated that ARBB1 (arrestin beta 1) promotes hepatocellular carcinogenesis (HCC). ...Inhibition of auto …
The hepatitis B virus X protein (HBx) is involved in the process of hepatocellular carcinoma via the activation of various onc …
Mechanism Research and Application for Ginsenosides in the Treatment of Hepatocellular Carcinoma.
Zhou N, Mao F, Cheng S. Zhou N, et al. Biomed Res Int. 2023 Nov 16;2023:7214037. doi: 10.1155/2023/7214037. eCollection 2023. Biomed Res Int. 2023. PMID: 38027042 Free PMC article. Review.
Ginsenosides, the main active pharmacological ingredients of ginseng, have been widely used for the treatment of numerous carcinomas. Hepatocellular carcinoma (HCC) is 3(rd) leading malignant tumor in terms of mortality worldwide. ...Ginsenosides can significantly i …
Ginsenosides, the main active pharmacological ingredients of ginseng, have been widely used for the treatment of numerous carcinomas. Hep …
lncRNA TINCR Regulates Proliferation and Invasion of Hepatocellular Carcinoma Cells by Regulating the miR-375/ATG7 Axis.
Tang C, Yu H, Zheng Y, Feng W, Shen J. Tang C, et al. J Oncol. 2022 Sep 16;2022:8132403. doi: 10.1155/2022/8132403. eCollection 2022. J Oncol. 2022. PMID: 36157234 Free PMC article.
Luciferase reporter and Western blotting showed that lncRNA TINCR regulates the expression of ATG7 through miR-375, and the rescue experiment proved that lncRNA TINCR controls the invasion and proliferation of liver cancer cells via the miR-375/ATG7 signaling pathwa …
Luciferase reporter and Western blotting showed that lncRNA TINCR regulates the expression of ATG7 through miR-375, and the rescue ex …
SNRPD1 inhibition suppresses the proliferation of hepatocellular carcinoma and promotes autophagy through the PI3K/AKT/mTOR/4EBP1 pathway.
Wang H, Chen M, Yang C, Hu H, Jiang Y, Yang F, Lv L. Wang H, et al. Arch Biochem Biophys. 2023 Jul 15;743:109661. doi: 10.1016/j.abb.2023.109661. Epub 2023 May 31. Arch Biochem Biophys. 2023. PMID: 37268273
Our previous study suggested that SNRPD1 has diagnostic and prognostic value in hepatocellular carcinoma (HCC), but its role in tumor growth and biological behavior remains unknown. ...Mechanistic analyses demonstrated that SNRPD1 knockdown induced the increase of a …
Our previous study suggested that SNRPD1 has diagnostic and prognostic value in hepatocellular carcinoma (HCC), but its role i …
LncRNA DANCR promotes ATG7 expression to accelerate hepatocellular carcinoma cell proliferation and autophagy by sponging miR-222-3p.
Wang X, Cheng ML, Gong Y, Ma WJ, Li B, Jiang YZ. Wang X, et al. Eur Rev Med Pharmacol Sci. 2020 Sep;24(17):8778-8787. doi: 10.26355/eurrev_202009_22816. Eur Rev Med Pharmacol Sci. 2020. PMID: 32964966 Free article.
OBJECTIVE: LncRNA differentiation antagonizing non-protein coding RNA (DANCR) is an oncogene in various malignant cancers, including hepatocellular carcinoma (HCC). Autophagy is an intracellular self-digestion mechanism that accelerates the progression of HCC via pr …
OBJECTIVE: LncRNA differentiation antagonizing non-protein coding RNA (DANCR) is an oncogene in various malignant cancers, including hepa …
Intracellular alpha-fetoprotein interferes with all-trans retinoic acid induced ATG7 expression and autophagy in hepatocellular carcinoma cells.
Wang S, Feng R, Shi Y, Chen D, Weng H, Ding H, Zhang C. Wang S, et al. Sci Rep. 2021 Jan 25;11(1):2146. doi: 10.1038/s41598-021-81678-7. Sci Rep. 2021. PMID: 33495541 Free PMC article.
Retinoic acid and retinoid acid receptor (RA-RAR) signaling exhibits suppressive functions in the progression of hepatocellular carcinoma (HCC) through multiple mechanisms. However, whether RA-RAR signaling induces autophagy that contributes its anti-tumor activity …
Retinoic acid and retinoid acid receptor (RA-RAR) signaling exhibits suppressive functions in the progression of hepatocellular ca …
The role of autophagy in hepatocellular carcinoma: friend or foe.
Liu L, Liao JZ, He XX, Li PY. Liu L, et al. Oncotarget. 2017 Apr 18;8(34):57707-57722. doi: 10.18632/oncotarget.17202. eCollection 2017 Aug 22. Oncotarget. 2017. PMID: 28915706 Free PMC article. Review.
However, once a tumor is established, unbalanced autophagy will contribute to carcinoma cell survival under tumor microenvironment and in turn promote tumor growth and development. The dynamic role of autophagy can also apply on hepatocellular carcinoma (HCC) …
However, once a tumor is established, unbalanced autophagy will contribute to carcinoma cell survival under tumor microenvironment an …
81 results